不顾 (bú gù): to disregard, to ignore

In order to save time, he ran a red light regardless of traffic rules, and as a result, he was fined by the police.

She insisted on marrying that poor young man regardless of her family's opposition.

That firefighter rushed into the fire to save a little girl, disregarding his own safety.

He was so seriously ill, yet he disregarded the doctor's advice and still stayed up late working every day.

Xiaoming went out wearing only a thin jacket, ignoring the cold weather.

Regardless of her fatigue, she worked for twelve hours straight and finally completed the task.