浩劫 (hào jié): หายนะ

That massive earthquake was a calamity; thousands of people lost their homes.

The war brought a decade-long calamity to this country, and the economy nearly collapsed.

After the flood, the whole village was in a mess, as if it had gone through a calamity.

That epidemic was a calamity for the elderly, and many families were shattered as a result.